Volume 35, Issue 2

In recent years, multiple lines of evidence from human genetic and molecular studies have highlighted the importance of the autophagy lysosomal pathway (ALP) in Parkinson’s disease (PD). Genes such as GBA and LRRK2, which harbor some of the most common mutations associated with PD, have essential roles in the ALP. a-synuclein, encoded by the SNCA gene, is degraded mainly by the ALP, and mutations/multiplications in SNCA may lead to impairment of chaperone mediated autophagy or other ALP functions. Numerous other PD-related genes, such as PARK2, PINK1, TMEM175, SMPD1, CTSD, CTSB and many more, have also been reported to have important roles in the ALP. Understanding the relationship between ALP impairment and PD pathogenesis may be crucial for uncovering the mechanisms underlying PD, and for the development of long-awaited neuroprotective therapies. In this review, we will discuss the data linking the ALP to PD (other, atypical forms of Parkinsonism, will not be discussed in this review). We will focus on evidence from studies on specific genes and proteins, their roles in the ALP, and the potential mechanisms underlying the involvement of these genes in PD.

High temperature superconductivity, BCS theory and the mechanism of high temperature superconductivity are introduced. The author proposed, for the first time, the change of the electron cloud ions can be used as a new medium for electron pairing. Calculation results are given. The results show that the frequency of the change of the electron cloud is close to (and higher than at normal pressures) the frequency of the lattice vibration. It is possible to explain the phenomenon of high temperature superconductivity by using the change of electron cloud instead of lattice vibration.

Borderline personality disorder is a personality disorder marked by an ongoing pattern of varying moods, self-image, and behaviour. These symptoms often result in impulsive actions and problems in relationships. In fact, according to Psychology Today, from an outside perspective, a person with discouraged borderline might look a bit like someone with dependent personality disorder. This person displays signs of co-dependence in most relationships in life. People with borderline personality disorder may experience intense episodes of anger, depression, and anxiety that can last from a few hours to days. The study is focused in analysing Hedda’s psychosis in how she behaves, thinks, and feels. Hedda, who is one of the major characters in the play, suffers from this personality disorder. The purpose of the study is to understand that Hedda suffers from Psychosis borderline personality disorder. The writers choose to use it because it is very closest to apply in Hedda’s personality. In relation with the title and the background of the study, this article is formulated to answer the question on : What are the characteristics of Psychosis that occur in Henrik Ibsen’s Hedda Gabler? and How does the effect of psychosis in Henrik Ibsen’s Hedda Gabler? The finding serves that the existence of psychosis phenomenon is proved after the analysis is conducted. The phenomenon strengthen writer’s claim that the work of Henrik Ibsen’s was inspired by the condition of society in the period of the play creation, especially that of experienced by middle class society.

The panchromatic light absorption and excellent charge carrier transport properties in organo lead halide perovskites allowed to achieve an unprecedented power conversion efficiency in excess of 25% for thin film photovoltaics fabrication. To understand the underlying phenomena various comprehensive set of optical and electrical techniques have been employed to investigate the charge carrier dynamics in such devices. In this perspective, we aim to summarize the electrical transport properties of perovskite thin films by using (i) impedance spectroscopy (IS), (ii) space charge limited current (SCLC), (iii) field-effect transistors (FETs) and (iv) time-of-flight (TOF) methods. We have deliberated various equivalent circuit used to model the perovskite solar cells by means of IS. The SCLC technique provide vital electrical parameters such as mobility, activation energy, traps density and distribution, carrier concentration, density of states, etc. The TOF technique measures mobility as a primary parameter while the FETs configuration provide a valuable insight into the in-plane charge transport in perovskites thin films. We believe that these notable understanding will provide insights into charge carrier dynamics in perovskite materials and devices.

The objectives of this research were to find out types of English sentences acquired by boys and girls of four and five years old children. This research also aims to find the tendency of English acquisition between boys and girls. The sources or subjects of this research were 20 kindergarten students of K-2 David in TK Kristen Kalam Kudus Pematangsiantar, 11 boys and 9 girls. The research design is qualitative research design. The instrument of data collection used video recording to observe the subjects in real situation and naturally. The result reveals that, the types of English sentences acquired by boys and girls of four and five years old children are declarative, interrogative, imperative, and exclamatory sentences, which are boys acquired interrogative sentences much more in their conversation while girls acquired declarative sentences more than other types. Girls or females articulate better and acquire a more extensive vocabulary than males or boys.

This paper explores the application of queuing theory in cloud computing, emphasizing its potential to optimize service delivery, resource utilization, and cost efficiency. Queuing models, such as M/M/1 and M/G/s, are analyzed in the context of cloud services to address dynamic workloads and user demands. Implementation steps and code examples for each model are provided, highlighting key metrics like queue length, waiting time, server utilization, and blocking probability. A comparative analysis of these models illustrates their suitability for different scenarios, from single-server setups to complex systems with variable service times. The findings underline the importance of selecting appropriate queuing models to meet system-specific requirements and propose future enhancements to tackle challenges like impatient user behavior and resource constraints.